Based on ABO compatibility, which donor would be most appropriate for a renal transplant candidate with ABO type O?

Based on ABO compatibility, which donor would be most appropriate for a renal transplant candidate with ABO type O?

• A. O
• B. A
• C. B
• D. AB

Answer: (A)

ABO compatibility is determined by the recipient’s antibodies against A and B antigens. A person with type O blood has both anti-A and anti-B antibodies in their plasma and lacks A or B antigens on their own cells. For a kidney transplant, the donor organ should not carry A or B antigens that the recipient’s antibodies can target. A donor without A or B antigens (type O) presents no A or B targets, making it compatible with a type O recipient. Donors with A, B, or AB antigens would express antigens that the type O recipient’s antibodies would recognize, risking immediate rejection. Therefore, the most appropriate donor is type O.

ABO compatibility is determined by the recipient’s antibodies against A and B antigens. A person with type O blood has both anti-A and anti-B antibodies in their plasma and lacks A or B antigens on their own cells. For a kidney transplant, the donor organ should not carry A or B antigens that the recipient’s antibodies can target. A donor without A or B antigens (type O) presents no A or B targets, making it compatible with a type O recipient. Donors with A, B, or AB antigens would express antigens that the type O recipient’s antibodies would recognize, risking immediate rejection. Therefore, the most appropriate donor is type O.