Which antibody is not produced in response to hepatitis B vaccination?

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Study for the Stevens Immunology-Serology Test. Explore flashcards and multiple choice questions with detailed explanations and hints. Get exam ready now!

Multiple Choice

Which antibody is not produced in response to hepatitis B vaccination?

Explanation:
Hepatitis B vaccination trains the immune system using only the surface antigen, HBsAg. Because the vaccine presents HBsAg, the body makes antibodies against it—anti-HBs—which confer protective immunity. It does not include the core antigen (HBcAg) or the e antigen (HBeAg), so antibodies to those components (anti-HBc and anti-HBe) are not produced by vaccination. In particular, anti-HBc is a marker of natural HBV infection, not of vaccination. Therefore, the antibody that is not produced in response to hepatitis B vaccination is anti-HBc.

Hepatitis B vaccination trains the immune system using only the surface antigen, HBsAg. Because the vaccine presents HBsAg, the body makes antibodies against it—anti-HBs—which confer protective immunity. It does not include the core antigen (HBcAg) or the e antigen (HBeAg), so antibodies to those components (anti-HBc and anti-HBe) are not produced by vaccination. In particular, anti-HBc is a marker of natural HBV infection, not of vaccination. Therefore, the antibody that is not produced in response to hepatitis B vaccination is anti-HBc.

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